The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.
Epigenetic Therapy of Cancer Ebook
Preclinical Models and Treatment Approaches
By: Michael L?bbert
Publisher:
Springer
Print ISBN: 9783642384035, 364238403X
eText ISBN: 9783642384042, 3642384048
Copyright year: 2014
Format: PDF
Available from $ 159.00 USD
SKU: 9783642384042
?
